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The thyroid hormone thyroxine, in the form of levothyroxine sodium, will accelerate weight loss and thereby improve insulin sensitivity when combined with dietary intervention in horses. Treatment periods of 3—6 months are often needed to achieve desirable weight loss. At that time, the horse should be weaned off the medication over 3—4 wk. If feed intake is not limited concurrently, treatment with levothyroxine is unlikely to resolve clinical signs.


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Metformin is poorly absorbed in equids but may decrease postprandial glucose and insulin levels. It should be given 30 minutes before a meal if possible.

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However, the longterm efficacy and safety of metformin has not been established in horses. If it is used, blood glucose should be carefully monitored. Use of metformin should be discontinued if hypoglycemia is documented. Prevention of Equine Metabolic Syndrome Prevention of equine metabolic syndrome should focus on maintaining normal weight in horses, particularly in high-risk breeds.

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Because these horses may be more efficient users of ingested calories than others, it is imperative to feed appropriately to maintain an ideal condition score and not to use arbitrary feeding guidelines. Particular care should be exercised when turning horses on pasture during times of high-soluble carbohydrate content eg, spring and autumn. Key Points The inability to metabolize carbohydrates, also known as insulin dysregulation, is the key problem in horses with equine metabolic syndrome. High blood insulin concentrations lead to laminitis, which in turn can lead to devastating lameness, loss of use, and death.

Some breeds and lines of horses are at increased risk of developing EMS. This may be because they possess a "thrifty" gene and are more efficient metabolically than other horses. It is important to feed the amount that maintains a normal body condition, as it may be quite a bit less than is recommended in other breeds.

Many horses with EMS gain fat and develop laminitis when placed on pasture. Dietary management feeding low-carbohydrate hay is important to prevent bouts of laminitis.

The diagnosis of equine insulin dysregulation. Equine Vet Journal ; From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in as a service to the community. Common Veterinary Topics.

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Videos Figures Images Quizzes. Etiology and Pathogenesis of Equine Metabolic Syndrome. Clinical Findings of Equine Metabolic Syndrome. Diagnosis of Equine Metabolic Syndrome.


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  • Treatment for Equine Metabolic Syndrome. Prevention of Equine Metabolic Syndrome. Key Points. More Information. Test your knowledge. Parturient paresis, also called milk fever, can cause flaccid paralysis and circulatory collapse in dairy cows during or soon after parturition.

    Serum calcium levels must be corrected as soon as possible by administering intravenous calcium gluconate slowly over minutes. Which of the following signs is most consistent with too-rapid administration of intravenous calcium administration? Add to Any Platform. Excess adipose tissue on the neck, equine metabolic syndrome. Horse with equine metabolic syndrome. Pony with both equine metabolic syndrome and PPID. The underlying reason why some horses develop equine metabolic syndrome and others do not is not known.

    There is no clinical picture that is pathognomonic for insulin resistance. Tests to confirm insulin resistance and exclude PPID. Dietary management. Prevention of equine metabolic syndrome should focus on maintaining normal weight in horses, particularly in high-risk breeds. The inability to metabolize carbohydrates, also known as insulin dysregulation, is the key problem in horses with equine metabolic syndrome. Read more.

    2nd Edition

    Manual of Equine Gastroenterology. Manual of Equine Reproduction. Equine Surgery, 4th Edition. Equine Geriatric Medicine and Surgery. The Equine Manual. Equine Respiratory Medicine and Surgery. Manual of Aesthetic Surgery. Manual of Thoracic Surgery. Schwartz's Manual of Surgery. Manual of Retinal Surgery. The Equine Manual 2nd Edition. Manual of Equine Anesthesia and Analgesia. Manual of Equine Reproduction, 3rd Edition.

    Popular Features. New Releases. Categories: Equine Veterinary Medicine. Description This second edition of the popular resource serves as a ready reference for equine practitioners. It provides comprehensive coverage of all aspects of equine medicine and many surgical conditions. It is a hands-on, user-friendly text aimed at the busy practitioner, veterinary students, specialist equine technicians and others with an interest in horse health. It covers new topics, including intensive care, the pre-purchase examination, equine behavior, and anesthesia including euthanasia.

    Product details Format Paperback pages Dimensions x Infectious Diseases 2.

    The equine veterinary manual

    The Immune System 3. Equine Nutrition and Metabolic Diseases 4. Toxicology and Pharmacology 5. The Skin 6.